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Vasyljev V.A.
Municipal Polyclinic №16, medical center “Tecom”, Odessa (Ukraine)
Abstract / Introduction: The data used for nonalcoholic fatty liver disease (NAFLD) diagnostics, included: glucose tolerance indexes [ 1 ], body-mass index (BMI) [ 6 ], alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutaminetranspeptidase (Gamma-GT), total blood bilirubin and cholesterol, results of liver ultrasonic diagnistics (US): hyperechoic liver – steatosis[3]. The study confirmed legalon [2], vitamin E ( a- tocopherol ) [4] and ursodeoxycholic acid [5] biochemical effective response in individuals with NAFLD.
Methods: The total number of examined post-voyage individuals included 159 crew members (males) at the age between 25 and 59 (average 48,2-5,1 years old)
Objective: NAFLD diagnostics possibilities in marine transport individuals – crew members, during post-voyage period and treatment effectiveness after ursofalk, vitamin E and legalon .
Complex patients examination involved evaluation of seniority, occupational hazards, anamnesis, complaints, laboratory study results, BMI, liver US test, as well as blood fibro-test or fibroscan in some patients.
The first study group included 30 persons who were prescribed ursofalk with the dose of 10-30 mg/kg/day for 30 – 90 days period. The second group included 25 persons, who were prescribed ursofalk10-30 mg/kg/day for 30 – 90 days, vitamin E with the dose of 400 – 1200 mg/kg/day for 20 – 30 days, legalon 280 – 320 mg/kg/day for 30 – 90 days.
Results: The NAFLD diagnosis was confirmed in 55 cases. 1st stage Hepatic fibrosis was detected in 17 persons after fibrotest or fibroscan.
Clinical improvement was observed in 23 NAFLD cases (92,0%) in the1st group and in 21 cases (91.4%) in the 2nd group. US liver scan demonstrated liver size reduction in 23 cases (85,2%) in the 1st group and 19 cases (86,4%) in the 2nd group as well as with signs of steatosis, in 13 (81,3%) and 13 (86,7%) correspondingly. In the 1st group study was obtained statistically-valid (р< 0,05) reduction of ALT indexes in the 1st group and statistically-valid (р< 0,05) reduction of total bilirubin, ALT and Gamma-GT in the 2nd group.
Discussion / Conclusion: Complex examination of marine transport individuals – crew members during post-voyage period allows to detect NAFLD. Therapy results confirmed the medical reports on the ursofalk, vitamin E and legalon effectiveness.
References
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